NR4A1 (pS351) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
NR4A1 (pS351) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031951
tested applications
ELISA, DB
Description
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NR4A1 (pS351) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser351 |
| Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, DB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P22736 |
| Alias | HMR,N10,TR3,NP10,GFRP1,NAK-1,NGFIB,NUR77,Early response protein NAK1,Orphan nuclear receptor HMR,Testicular receptor 3 |
| Background | Antibody anti-NR4A1 |
| Status | RUO |
Descripción
Nuclear receptor subfamily 4 group A member 1 (NR4A1), also known as Nur77, is a nuclear receptor involved in regulating a variety of physiological processes, including cell growth, apoptosis, immune responses, and metabolism NR4A1 is activated in response to signaling molecules, such as cytokines and hormones, and regulates the expression of genes involved in inflammation, cell survival, and differentiation It plays a key role in controlling apoptosis, particularly in immune cells, where it helps eliminate damaged or infected cells NR4A1 is also involved in regulating metabolism, including glucose and lipid homeostasis, by modulating the expression of genes that control energy balance Dysregulation of NR4A1 has been linked to various diseases, including cancer, autoimmune diseases, and cardiovascular conditions, where altered NR4A1 signaling contributes to tumorigenesis, inflammation, and metabolic dysfunction Additionally, NR4A1’s role in regulating immune responses and apoptosis makes it a potential target for therapeutic interventions aimed at controlling inflammation and promoting cell death in cancerous or infected cells
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