Non Catalytic Region of Tyrosine Kinase Adaptor Protein 1 (NCK1) Antibody
364€ (0.1 mg)
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Name
Non Catalytic Region of Tyrosine Kinase Adaptor Protein 1 (NCK1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139781
Tested Applications
WB, IF/ICC
Description
NCK1 Antibody is a Mouse Monoclonal against NCK1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Non Catalytic Region of Tyrosine Kinase Adaptor Protein 1 (NCK1) Immunogen: Purified recombinant second SH3 domain of Human Nck1 fused to GST. |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | V813 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P16333 |
| Gene ID | 4690 |
| Alias | NCK1, NCK, NCKalpha, nck-1, NCK adaptor protein 1 |
| Background | Antibody anti-NCK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
NCK1 is a cytoplasmic adaptor protein containing three SH3 domains and one SH2 domain, which allows it to mediate interactions between receptor tyrosine kinases (RTKs) and downstream effectors in signaling pathways. NCK1 is involved in actin cytoskeleton reorganization, cell motility, and immune synapse formation by linking signaling proteins such as WASP, WAVE, and PAK1. It plays key roles in processes like cell migration, proliferation, and T-cell activation. NCK1 is highly expressed in various tissues and regulates growth factor receptor signaling, including pathways like MAPK/ERK and PI3K. Dysregulation of NCK1 is associated with cancer progression, metastasis, and immune system dysfunction. Knockout studies show defects in actin dynamics, impaired cell movement, and reduced T-cell activation, highlighting its importance in cytoskeletal signaling and cellular communication.
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