NKG2-C Type II Integral Membrane Protein (KLRC2) Antibody (Biotin)

Este producto es parte de KLRC - killer cell lectin like receptor C
Product Graph
169€ (20 µg)

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935106861
info@markelab.com
name
NKG2-C Type II Integral Membrane Protein (KLRC2) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx304303
tested applications
ELISA

Description

KLRC2 Antibody (Biotin) is a Rabbit Polyclonal against KLRC2 conjugated to Biotin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
NKG2-C Type II Integral Membrane Protein (KLRC2)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P26717
Gene ID
3822
OMIM
602891
Alias
NKG2-C type II integral membrane protein,NKG2C,CD159c,NKG2-C,CD159 antigen-like family member C,NK cell receptor C,NKG2-C-activating NK receptor
Background
Antibody anti-KLRC2
Status
RUO

Descripción

Killer cell lectin like receptor C2 (KLRC2), commonly referred to as NKG2C, is an activating receptor expressed on NK cells and some T cells. Unlike KLRC1, KLRC2 interacts with HLA-E to initiate stimulatory signals that enhance cytotoxic responses and cytokine production. KLRC2 signaling is mediated through its association with the adaptor molecule DAP12, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) responsible for triggering downstream signaling cascades. This receptor is pivotal in the immune response against infected or transformed cells, particularly in conditions where HLA-E is overexpressed due to stress or infection. KLRC2 is also involved in adaptive immune responses, contributing to the expansion and memory-like properties of NK cells, especially during cytomegalovirus (CMV) infections. Targeting KLRC2 pathways is being explored to potentiate immune responses in infectious diseases and cancer therapies.

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