Human NKG2-C Type II Integral Membrane Protein (KLRC2) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human NKG2-C Type II Integral Membrane Protein (KLRC2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067656
tested applications
WB, SDS-PAGE
Description
Recombinant NKG2-C Type II Integral Membrane Protein (KLRC2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | NKG2-C Type II Integral Membrane Protein (KLRC2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 23.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg19-Leu190 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P26717 |
| Gene ID | 3822 |
| OMIM | 602891 |
| Alias | NKG2-C type II integral membrane protein,NKG2C,CD159c,NKG2-C,CD159 antigen-like family member C,NK cell receptor C,NKG2-C-activating NK receptor |
| Background | Protein KLRC2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer cell lectin like receptor C2 (KLRC2), commonly referred to as NKG2C, is an activating receptor expressed on NK cells and some T cells. Unlike KLRC1, KLRC2 interacts with HLA-E to initiate stimulatory signals that enhance cytotoxic responses and cytokine production. KLRC2 signaling is mediated through its association with the adaptor molecule DAP12, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) responsible for triggering downstream signaling cascades. This receptor is pivotal in the immune response against infected or transformed cells, particularly in conditions where HLA-E is overexpressed due to stress or infection. KLRC2 is also involved in adaptive immune responses, contributing to the expansion and memory-like properties of NK cells, especially during cytomegalovirus (CMV) infections. Targeting KLRC2 pathways is being explored to potentiate immune responses in infectious diseases and cancer therapies.
Related Products
NKG2-C Type II Integral Membrane Protein (KLRC2) Antibody
KLRC2 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Ver Producto
Human NKG2-C Type II Integral Membrane Protein (KLRC2) Protein
Recombinant NKG2-C Type II Integral Membrane Protein (KLRC2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto
NKG2-C Type II Integral Membrane Protein (KLRC2) Antibody
Polyclonal Antibody to NKG2-C Type II Integral Membrane Protein (KLRC2).
Ver Producto