Human NKG2-C Type II Integral Membrane Protein (KLRC2) Protein

Name: Human NKG2-C Type II Integral Membrane Protein (KLRC2) Protein
Brand: Abbexa
SKU: abx067656
Price: 234 EUR
Availability: OnlineOnly

Este producto es parte de KLRC - killer cell lectin like receptor C

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein KLRC2

proveedor

Abbexa

reference

abx067656

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant NKG2-C Type II Integral Membrane Protein (KLRC2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

Killer cell lectin like receptor C2 (KLRC2), commonly referred to as NKG2C, is an activating receptor expressed on NK cells and some T cells. Unlike KLRC1, KLRC2 interacts with HLA-E to initiate stimulatory signals that enhance cytotoxic responses and cytokine production. KLRC2 signaling is mediated through its association with the adaptor molecule DAP12, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) responsible for triggering downstream signaling cascades. This receptor is pivotal in the immune response against infected or transformed cells, particularly in conditions where HLA-E is overexpressed due to stress or infection. KLRC2 is also involved in adaptive immune responses, contributing to the expansion and memory-like properties of NK cells, especially during cytomegalovirus (CMV) infections. Targeting KLRC2 pathways is being explored to potentiate immune responses in infectious diseases and cancer therapies.

Características del producto

origin

Human

host

E. coli

immunogen target

NKG2-C Type II Integral Membrane Protein (KLRC2)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 23.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg19-Leu190 Tag: N-terminal His tag

expression

Recombinant

purity

> 95%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

KLRC2

dry ice

availability

Shipped within 5-7 working days.

alias

NKG2-C type II integral membrane protein,NKG2C,CD159c,NKG2-C,CD159 antigen-like family member C,NK cell receptor C,NKG2-C-activating NK receptor

uniprot id

https://www.uniprot.org/uniprotkb/P26717

gene id

https://www.ncbi.nlm.nih.gov/gene/3822

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

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NKG2-C Type II Integral Membrane Protein (KLRC2) Antibody

proveedor

Abbexa

reference

abx034036

Tested Applications

ELISA, WB, IHC, FCM

reactivity

Human

status

RUO

clonality

Polyclonal

KLRC2 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cel...

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