Nitric Oxide Synthase, Inducible (NOS2) Antibody
383.5€ (100 µl)
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name
Nitric Oxide Synthase, Inducible (NOS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015943
tested applications
ELISA, WB, IHC, FCM
Description
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities.This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines.Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nitric Oxide Synthase, Inducible (NOS2) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4843, 18126, 24599 |
| Alias | Inosl,Macrophage NOS,MAC-NOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2,NOS2A |
| Background | Antibody anti-NOS2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NOS2, also known as inducible nitric oxide synthase (iNOS), is an enzyme responsible for the production of nitric oxide (NO), a key signaling molecule involved in immune defense, inflammation, and vasodilation NOS2 is primarily expressed in macrophages, neutrophils, and other immune cells upon stimulation by pro-inflammatory cytokines like IFN-γ, TNF-α, or microbial components such as lipopolysaccharide (LPS) NOS2-derived NO plays a critical role in host defense by killing pathogens, including bacteria, fungi, and parasites, through oxidative stress and inhibition of microbial enzymes Dysregulated NOS2 activity contributes to chronic inflammation, sepsis, and tissue damage observed in diseases such as autoimmune disorders, asthma, and neurodegeneration In cancers, NO produced by NOS2 can have dual effects, promoting tumor growth by inducing angiogenesis and suppressing immune responses or inhibiting tumor progression through cytotoxicity Regulation of NOS2 is of therapeutic interest for modulating inflammation and oxidative stress in infectious diseases, cardiovascular dysfunction, and cancer
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