NGAL/LCN2 Antibody is a Rabbit Polyclonal antibody against NGAL. Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2)
Rabbit
Unconjugated
Liquid
WB, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
LCN2
No
Shipped within 5-10 working days.
NP_005555.2
This product is for research use only.
Precio a consultar
Ver másNGAL Antibody is a Rabbit Polyclonal antibody against NGAL. NGAL (lipocalin 2) is a protein-coding gene. Diseases associ...
175€ (20 µl)
Ver másNGAL/LCN2 Antibody is a Rabbit Polyclonal antibody against NGAL. Iron-trafficking protein involved in multiple processes...
175€ (20 µl)
Ver más