Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody
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Description
NGAL/LCN2 Antibody is a Rabbit Polyclonal antibody against NGAL. Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC-P: 1/25 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS, pH 7.4, containing 0.05% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P80188 |
| Gene ID | 3934 |
| NCBI Accession | NP_005555.2 |
| OMIM | 600181 |
| Background | Antibody anti-LCN2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
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Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody
NGAL Antibody is a Rabbit Polyclonal antibody against NGAL. NGAL (lipocalin 2) is a protein-coding gene. Diseases associated with NGAL include insulin resistance, and pancreatic cancer. GO annotations related to this gene include iron ion binding and protein homodimerization activity. An important paralog of this gene is LCN12.
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Neutrophil Gelatinase Associated Lipocalin / NGAL (LCN2) Antibody
NGAL/LCN2 Antibody is a Rabbit Polyclonal antibody against NGAL. Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis.
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