Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1) Antibody
Pida mas información
935106861
info@markelab.com
Precio
250€ (80 µl)
Antibody anti-NTRK1
proveedor
Abbexareference
abx025227Tested Applications
ELISA, WBreactivity
Mousestatus
RUOclonality
MonoclonalDescripción
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Background
Neurotrophic receptor tyrosine kinase 1 (NTRK1) is an essential receptor that binds with nerve growth factor (NGF), initiating critical signaling cascades required for the survival, differentiation, and functional maintenance of neurons, particularly within the peripheral nervous system. Beyond supporting neuronal growth, NTRK1 contributes to injury responses, helping facilitate neuronal repair and regeneration. Dysregulation or mutations in NTRK1 have been implicated in neurodegenerative diseases, such as Charcot-Marie-Tooth disease, as well as in certain cancers, making it a significant target for therapeutic research and drug development efforts.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Mouse
immunogen target
Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NTRK1
dry ice
No
availability
Shipped within 5-10 working days.
alias
MTC,TRK,TRK1,TRKA,rk-A,p140-TrkA,Tyrosine kinase receptor A,TRK1-transforming tyrosine kinase protein,Neurotrophic tyrosine kinase receptor type 1,High affinity nerve growth factor receptor
uniprot id
note
This product is for research use only.
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