Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1) Antibody
Pida mas información
935106861
info@markelab.com
Precio
175€ (20 µl)
Antibody anti-NTRK1
proveedor
Abbexareference
abx001710Tested Applications
WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
NTRK1 Antibody is a Rabbit Polyclonal antibody against NTRK1. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Background
Neurotrophic receptor tyrosine kinase 1 (NTRK1) is an essential receptor that binds with nerve growth factor (NGF), initiating critical signaling cascades required for the survival, differentiation, and functional maintenance of neurons, particularly within the peripheral nervous system. Beyond supporting neuronal growth, NTRK1 contributes to injury responses, helping facilitate neuronal repair and regeneration. Dysregulation or mutations in NTRK1 have been implicated in neurodegenerative diseases, such as Charcot-Marie-Tooth disease, as well as in certain cancers, making it a significant target for therapeutic research and drug development efforts.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NTRK1
dry ice
No
availability
Shipped within 5-10 working days.
alias
MTC,TRK,TRK1,TRKA,rk-A,p140-TrkA,Tyrosine kinase receptor A,TRK1-transforming tyrosine kinase protein,Neurotrophic tyrosine kinase receptor type 1,High affinity nerve growth factor receptor
uniprot id
NCBI accession
NP_002520.2
note
This product is for research use only.
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