Neuroserpin (SERPINI1) Antibody

Este producto es parte de SERPINI1 - serpin family I member 1
Product Graph
416€ (200 µl)

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935106861
info@markelab.com
name
Neuroserpin (SERPINI1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433030
tested applications
P-ELISA, WB, IHC

Description

Neuroserpin Antibody is a Goat Polyclonal antibody against Neuroserpin.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Neuroserpin (SERPINI1)
Host
Goat
Reactivity
Human
Recommended Dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB, IHC
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
5274
NCBI Accession
NP_005016.1
Alias
PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1
Background
Antibody anti-SERPINI1
Status
RUO
Note
Concentration: 0.5 mg/ml -

Descripción

SERPINI1 (serpin family I member 1) is a gene encoding the neuroserpin protein, a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins, neuroserpin is primarily expressed in the central nervous system, where it plays a critical role in regulating proteolytic activity, particularly by inhibiting tissue-type plasminogen activator (tPA). The balance between neuroserpin and tPA is crucial for neural development, synaptic plasticity, and maintaining the integrity of neuronal tissues. SERPINI1 mutations are associated with certain neurodegenerative diseases, notably familial encephalopathy with neuroserpin inclusion bodies (FENIB), a condition characterized by the accumulation of misfolded neuroserpin proteins in neurons. This leads to neurodegeneration, progressive cognitive decline, and other neurological impairments.
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