This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Neuroserpin (NSP) Antibody is a Mouse Monoclonal antibody against Neuroserpin (NSP).
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL)Neuroserpin is a protein that in humans is encoded by the SERPINI1 gen. Neuroserpin inhibits the activity of an enzyme called tissue plasminogen activator (tPA), which plays a role in cell movement (migration), blood clotting, and inflammation.
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle central reactivo (RCL). La neuroserpina es una proteína que en los humanos está codificada por SERPINI1. gen. La neuroserpina inhibe la actividad de una enzima llamada activador del plasminógeno tisular (tPA), que desempeña un papel en el movimiento celular (migración), la coagulación sanguínea y la inflamación.
Primary Antibodies
Monoclonal
Human
Neuroserpin (NSP)
Mouse
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by Protein A and Protein G affinity chromatography.
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
1 ml
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
NSP
No
Please enquire.
This product is for research use only.
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