Neuropilin 1 (NRP1) Antibody Pair

Product specifications

Antibody Pairs

Neuropilin 1 (NRP1)

Human

Detection Antibody Biotinilated

Sandwich

Dilute the Capture Antibody 125-fold with Coating Buffer.  Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent.  Optimal dilutions/concentrations should be determined by the end user.

5 × 96 tests

10 × 96 tests

Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody)

Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user.

ELISA

The Capture and Detection Antibody both contain 0.1% sodium azide.

Please enquire.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Vascular endothelial cell growth factor 165 receptor,NP1,NRP,BDCA4,CD304,VEGF165R,

Antibody Pair for NRP1

RUO

This antibody pair contains ( 5 x 96 det):    Detection:  50 µg  Capture:  200 µg  Standard:  2 µg

This product is for research use only.

Descripción

Neuropilin-1 (NRP1) is a multifunctional transmembrane glycoprotein that plays critical roles in multiple physiological processes, including vascular development, neural guidance, immune modulation, and cancer progression. First characterized as a receptor involved in the guidance of axons, NRP1 is now known to act as a co-receptor for various ligands, including vascular endothelial growth factor (VEGF) and semaphorin family proteins, which control angiogenesis and axonal guidance, respectively. NRP1 is widely expressed in endothelial cells, neurons, immune cells, and several tumor cell types. Its role in mediating signal transduction for multiple growth factors makes it highly significant in both normal developmental biology and pathologies, including cancer and cardiovascular diseases. NRP1’s structure allows it to interact with a variety of ligands, facilitating its participation in different signaling pathways. Importantly, NRP1 lacks intrinsic kinase activity and instead functions by associating with other receptor complexes. This co-receptor capability is vital for its role in angiogenesis, where it enhances VEGF signaling by complexing with VEGF receptors (particularly VEGFR2), and in immune regulation, where it modulates T cell activity and antigen presentation. NRP1 has therefore become a target of interest for therapeutic intervention in diseases involving abnormal cell growth, such as cancer and chronic inflammatory conditions.

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