Family main features
Neuropilin-1 (NRP1) is a multifunctional transmembrane glycoprotein that plays critical roles in multiple physiological processes, including vascular development, neural guidance, immune modulation, and cancer progression. First characterized as a receptor involved in the guidance of axons, NRP1 is now known to act as a co-receptor for various ligands, including vascular endothelial growth factor (VEGF) and semaphorin family proteins, which control angiogenesis and axonal guidance, respectively. NRP1 is widely expressed in endothelial cells, neurons, immune cells, and several tumor cell types. Its role in mediating signal transduction for multiple growth factors makes it highly significant in both normal developmental biology and pathologies, including cancer and cardiovascular diseases.
NRP1’s structure allows it to interact with a variety of ligands, facilitating its participation in different signaling pathways. Importantly, NRP1 lacks intrinsic kinase activity and instead functions by associating with other receptor complexes. This co-receptor capability is vital for its role in angiogenesis, where it enhances VEGF signaling by complexing with VEGF receptors (particularly VEGFR2), and in immune regulation, where it modulates T cell activity and antigen presentation. NRP1 has therefore become a target of interest for therapeutic intervention in diseases involving abnormal cell growth, such as cancer and chronic inflammatory conditions.
Neuropilin-1 is a large, single-pass type I transmembrane protein that consists of several distinct extracellular domains, a transmembrane region, and a short cytoplasmic tail. The distinct structural domains of NRP1 enable it to interact with diverse ligands and participate in multiple signaling cascades.
Extracellular Domain:
Transmembrane Domain:
Intracellular (Cytoplasmic) Tail:
NRP1 belongs to the neuropilin family of receptors, which includes two main isoforms: neuropilin-1 (NRP1) and neuropilin-2 (NRP2). While NRP1 is expressed in a wide range of tissues, NRP2 has a more restricted expression pattern. These two receptors have overlapping but distinct ligand specificities; for example, NRP1 primarily binds VEGF-A isoforms and semaphorin-3A, whereas NRP2 binds VEGF-C/D and semaphorin-3F. Both receptors can heterodimerize, further expanding the range of signaling possibilities and allowing for fine-tuned regulation of cellular responses.
NRP1 has diverse functions due to its role as a co-receptor for different ligand-receptor complexes:
Angiogenesis:
Axon Guidance and Neural Development:
Immune Modulation:
Cancer and Tumor Progression:
Cardiovascular Development:
NRP1 has significant clinical relevance in a range of diseases, particularly in cancer, vascular diseases, and immune-related conditions:
Cancer Therapy:
Vascular and Cardiovascular Diseases:
Immune Dysregulation and Autoimmunity:
Neurological Disorders:
Neuropilin-1 (NRP1) is a versatile receptor that plays essential roles in angiogenesis, neural development, immune regulation, and cancer progression. Structurally, NRP1 is a type I transmembrane protein featuring an extracellular domain with ligand-binding motifs (CUB, coagulation factor homology, and MAM domains), a transmembrane region, and a short cytoplasmic tail with a PDZ-binding motif. This structure enables it to function as a co-receptor for a variety of ligands, including VEGF and semaphorins, allowing it to modulate several signaling pathways despite lacking intrinsic kinase activity.
NRP1’s roles in health and disease are varied. In normal physiology, it contributes to the development and maintenance of vascular and neural structures and plays a role in immune tolerance. In pathology, particularly cancer, NRP1 is associated with enhanced tumor angiogenesis, invasion, and metastasis. Its relevance extends to cardiovascular diseases and immune-related conditions, where dysregulated NRP1 activity contributes to disease progression.
Therapeutically, NRP1 is an attractive target. Blocking NRP1 interactions could inhibit tumor growth, reduce inflammation, and restore vascular integrity in diseases. Research continues to uncover the full spectrum of NRP1’s functions and potential as a therapeutic target in cancer, vascular diseases, and immune modulation.
neuropilin 1 (NRP1)
Vascular endothelial cell growth factor 165 receptor,NP1,NRP,BDCA4,CD304,VEGF165R,
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con NRP1 - neuropilin 1
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NRP1 | abx356821 | Chicken Neuropilin 1 (NRP1) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 3.906 pg/ml - 250 pg/ml | 2.35 pg/ml | 662.5 | 96 tests | RUO | |
FineTest | NRP1 | EH1959 | Human NRP1(Neuropilin-1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | O14786 | RUO | ||
Abbexa | NRP1 | abx197343 | Human Neuropilin 1 (NRP1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | NRP1 | abx152506 | Human Neuropilin 1 (NRP1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 62.5 pg/ml - 4000 pg/ml | < 26.2 pg/ml | 618.75 | 96 tests | O14786, E9PEP6, Q5T7F0, Q6X907, Q5JWQ6, E7EX60, Q5JWQ4, V9GYL7, H0Y4A0, Q9H2D7, Q9H2D9, Q5JWQ2, H0Y4N6, H0Y7Z2, Q9H2D8, Q7Z5M2 | RUO |
Abbexa | NRP1 | abx251281 | Human Neuropilin 1 (NRP1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.63 pg/ml - 1000 pg/ml | 9.4 pg/ml | 525 | 96 tests | O14786 | RUO |
Abbexa | NRP1 | abx190338 | Human Neuropilin 1 (NRP1) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 27.4 pg/ml - 20000 pg/ml | < 11.4 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | NRP1 | abx491893 | Mouse Neuropilin 1 (NRP1) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.4 pg/ml | 812.5 | 96 tests | P97333 | RUO |
Abbexa | NRP1 | abx154457 | Mouse Neuropilin 1 (NRP1) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 13.4 pg/ml | 618.75 | 96 tests | P97333 | RUO |
FineTest | NRP1 | ER1971 | Rat NRP1(Neuropilin-1) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | Q9QWJ9 | RUO | ||
Abbexa | NRP1 | abx491894 | Rat Neuropilin 1 (NRP1) CLIA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.053 ng/ml | 812.5 | 96 tests | Q9QWJ9, Q9QX38 | RUO |
Abbexa | NRP1 | abx570667 | Rat Neuropilin 1 (NRP1) ELISA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 15.63 pg/ml - 1000 pg/ml | 9.38 pg/ml | 587.5 | 96 tests | Q9QWJ9 | RUO |
Abbexa | NRP1 | abx155886 | Rat Neuropilin 1 (NRP1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | Q9QWJ9, Q9QX38 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NRP1 | abx101004 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | O14786 | RUO | |
Abbexa | NRP1 | abx101005 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | O14786 | RUO | |
Abbexa | NRP1 | abx146308 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | NRP1 | abx270902 | Neuropilin 1 (NRP1) Antibody (PE) | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | PE | FCM | 575 | 100 tests | RUO | ||
Abbexa | NRP1 | abx235680 | Neuropilin 1 (NRP1) Antibody | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | O14786 | RUO | |
Abbexa | NRP1 | abx320048 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | O14786 | RUO | |
Abbexa | NRP1 | abx270140 | Neuropilin 1 (NRP1) Antibody | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | NRP1 | abx376532 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | IgG | Unconjugated | ELISA, IHC | 243.75 | 50 µg | O14786 | RUO |
Abbexa | NRP1 | abx274542 | Neuropilin 1 (NRP1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | NRP1 | abx270438 | Neuropilin 1 (NRP1) Antibody (FITC) | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | FITC | FCM | 475 | 100 tests | RUO | ||
Abbexa | NRP1 | abx370466 | Neuropilin 1 (NRP1) Antibody Pair | Human | Neuropilin 1 (NRP1) | ELISA | 1325 | 5 × 96 tests | RUO | |||||
Abbexa | NRP1 | abx034213 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | O14786 | RUO | |
Abbexa | NRP1 | abx272028 | Neuropilin 1 (NRP1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | NRP1 | abx273765 | Neuropilin 1 (NRP1) Antibody (FITC) | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | FITC | WB, IHC, IF/ICC | 400 | 200 µl | RUO | ||
Abbexa | NRP1 | abx131786 | Neuropilin 1 (NRP1) Antibody | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | O14786 | RUO | |
Abbexa | NRP1 | abx270670 | Neuropilin 1 (NRP1) Antibody (APC) | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | APC | FCM | 662.5 | 100 tests | RUO | ||
Abbexa | NRP1 | abx224175 | Neuropilin 1 (NRP1) Antibody | Human | Monoclonal | Mouse | Neuropilin 1 (NRP1) | ELISA, WB, FCM | 362.5 | 100 µl | O14786 | RUO | ||
Abbexa | NRP1 | abx114089 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA | 612.5 | 100 µl | O14786 | RUO | |
Abbexa | NRP1 | abx241253 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, IHC | 250 | 50 µl | O14786 | RUO | |
Abbexa | NRP1 | abx329136 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O14786 | RUO | |
Abbexa | NRP1 | abx327621 | Neuropilin 1 (NRP1) Antibody | Human | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | O14786 | RUO | |
Abbexa | NRP1 | abx101008 | Neuropilin 1 (NRP1) Antibody | Mouse | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P97333 | RUO | |
Abbexa | NRP1 | abx101006 | Neuropilin 1 (NRP1) Antibody | Mouse | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P97333 | RUO | |
Abbexa | NRP1 | abx101007 | Neuropilin 1 (NRP1) Antibody | Mouse | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P97333 | RUO | |
Abbexa | NRP1 | abx101009 | Neuropilin 1 (NRP1) Antibody | Mouse | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P97333 | RUO | |
Abbexa | NRP1 | abx272729 | Neuropilin 1 (NRP1) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Biotin | WB, IHC, IF/ICC | 337.5 | 200 µl | RUO | ||
Abbexa | NRP1 | abx273203 | Neuropilin 1 (NRP1) Antibody (Biotin) | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | NRP1 | abx274121 | Neuropilin 1 (NRP1) Antibody (FITC) | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | FITC | WB, IHC, IF/ICC | 425 | 200 µl | RUO | ||
Abbexa | NRP1 | abx130134 | Neuropilin 1 (NRP1) Antibody | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QWJ9 | RUO | |
Abbexa | NRP1 | abx101012 | Neuropilin 1 (NRP1) Antibody | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QWJ9 | RUO | |
Abbexa | NRP1 | abx101011 | Neuropilin 1 (NRP1) Antibody | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QWJ9 | RUO | |
Abbexa | NRP1 | abx101010 | Neuropilin 1 (NRP1) Antibody | Rat | Polyclonal | Rabbit | Neuropilin 1 (NRP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QWJ9 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NRP1 | abx068260 | Rat Neuropilin 1 (NRP1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2062.5 | 1 mg | Q9QWJ9 | RUO |
Abbexa | NRP1 | abx068262 | Mouse Neuropilin 1 (NRP1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P97333 | RUO |
Abbexa | NRP1 | abx620035 | Human Neuropilin 1 (NRP1) Protein | Human | Recombinant | Mammalian cells | SDS-PAGE | 287.5 | 50 µg | O14786 | RUO | |
Abbexa | NRP1 | abx068258 | Rat Neuropilin 1 (NRP1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2062.5 | 1 mg | Q9QWJ9 | RUO |
Abbexa | NRP1 | abx068256 | Human Neuropilin 1 (NRP1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | O14786 | RUO |
Abbexa | NRP1 | abx068257 | Mouse Neuropilin 1 (NRP1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P97333 | RUO |
Abbexa | NRP1 | abx068261 | Rat Neuropilin 1 (NRP1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9QWJ9 | RUO |
Abbexa | NRP1 | abx068263 | Mouse Neuropilin 1 (NRP1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P97333 | RUO |
Abbexa | NRP1 | abx620031 | Human Neuropilin 1 (NRP1) Protein | Human | Recombinant | E. coli | SDS-PAGE | 250 | 50 µg | O14786 | RUO | |
Abbexa | NRP1 | abx068264 | Mouse Neuropilin 1 (NRP1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P97333 | RUO |
Abbexa | NRP1 | abx068259 | Human Neuropilin 1 (NRP1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | O14786 | RUO |
Abbexa | NRP1 | abx068265 | Rat Neuropilin 1 (NRP1) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q9QWJ9 | RUO |
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