Neuropeptide Y Receptor Y2 (NPY2R) Antibody
416€ (200 µl)
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935106861
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name
Neuropeptide Y Receptor Y2 (NPY2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431462
tested applications
P-ELISA, WB
Description
NPY2R Antibody is a Goat Polyclonal antibody against NPY2R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuropeptide Y Receptor Y2 (NPY2R) |
| Host | Goat |
| Reactivity | Rat |
| Recommended Dilution | P-ELISA: 1/4000, WB: 0.1-0.3 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P49146 |
| Gene ID | 4887, 18167, 66024 |
| NCBI Accession | NP_032757.1 |
| OMIM | 162642 |
| Alias | NPY2R,NPY2-R,neuropeptide Y receptor type 2,NPY-Y2 receptor |
| Background | Antibody anti-NPY2R |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
NPY2R is a G protein-coupled receptor that binds neuropeptide Y (NPY) and peptide YY (PYY) with high affinity. NPY2R is predominantly expressed in the central nervous system (CNS), particularly in the hypothalamus, hippocampus, and brainstem, as well as in peripheral tissues such as the gastrointestinal tract. It functions as an autoreceptor to inhibit the release of NPY and modulates appetite suppression, energy homeostasis, and gastrointestinal motility. NPY2R couples to Gi/o proteins, reducing adenylate cyclase activity, cAMP levels, and neurotransmitter release. Activation of NPY2R reduces food intake and promotes energy expenditure, making it a key target for anti-obesity therapies. It also plays roles in neuroprotection, stress regulation, and cardiovascular function. Dysregulation of NPY2R signaling is associated with metabolic disorders, anxiety, and inflammatory conditions. NPY2R agonists are being developed to treat obesity by enhancing satiety and energy expenditure, highlighting its role as a critical regulator of feeding behavior and metabolism.
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