Neural Cell Adhesion Molecule 2 (NCAM2) Antibody
292.5€ (80 µl)
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935106861
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name
Neural Cell Adhesion Molecule 2 (NCAM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030926
tested applications
ELISA, WB
Description
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neural Cell Adhesion Molecule 2 (NCAM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15394 |
| Alias | NCAM21,N-CAM-2 |
| Background | Antibody anti-NCAM2 |
| Status | RUO |
Descripción
Neural Cell Adhesion Molecule 2 (NCAM2), also known as OCAM (Olfactory Cell Adhesion Molecule), is another member of the immunoglobulin (Ig) superfamily that mediates cell adhesion and neuronal connectivity. NCAM2 shares structural similarities with NCAM1, including five Ig-like domains and two fibronectin type III domains in its extracellular region. However, NCAM2 has distinct roles in the olfactory system and brain development. It is highly expressed in olfactory neurons, where it regulates axon guidance and synaptic targeting. NCAM2 is crucial for neuronal differentiation and the establishment of specific neural circuits, particularly in the hippocampus and olfactory bulb. It mediates homophilic binding (interaction with identical molecules) to promote cell adhesion and structural organization. In the brain, NCAM2 is essential for the maintenance of synaptic connections and proper cortical layering.
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