Natural Killer Cell Receptor 2B4 (CD244) Antibody
377€ (100 µg)
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Name
Natural Killer Cell Receptor 2B4 (CD244) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231451
Tested Applications
ELISA, IHC
Description
CD244 Antibody is a Rabbit Polyclonal against CD244.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Natural Killer Cell Receptor 2B4 (CD244) Immunogen: CD244 molecule, natural killer cell receptor 2B4 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BZW8 |
| Gene ID | 51744 |
| OMIM | 605554 |
| Alias | Natural killer cell receptor 2B4,2B4,NAIL,Nmrk,NKR2B4,SLAMF4,NK cell activation-inducing ligand,SLAM family member 4,Signaling lymphocytic activation molecule 4 |
| Background | Antibody anti-CD244 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD244, also known as 2B4, is a receptor primarily expressed on natural killer (NK) cells and subsets of T cells. CD244 is encoded by the CD244 gene and belongs to the Signaling Lymphocyte Activation Molecule (SLAM) family within the immunoglobulin superfamily. This receptor plays a key role in immune regulation, functioning as a modulator of cytotoxic responses against infected or malignant cells. CD244 interacts with its ligand, CD48, a widely expressed protein found on hematopoietic cells, allowing it to mediate immune surveillance and inflammatory responses. CD244 has gained significant attention due to its dual role as an activating and inhibitory receptor on immune cells, where its function depends largely on the cellular context and specific signal cascades involved. Unlike many receptors that have a straightforward activating or inhibitory role, CD244 is unique in its ability to modulate immune responses through varying interactions with different proteins in NK cells and T cells.
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