NAD(P)HX Epimerase (NAXE) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
NAD(P)HX Epimerase (NAXE) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx213811
tested applications
ELISA, IHC
Description
APOA1BP Antibody is a Rabbit Polyclonal against APOA1BP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NAD(P)HX Epimerase (NAXE) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NCW5 |
| Gene ID | 128240 |
| Alias | NAXE AIBP,APOA1BP,YJEFN1 |
| Background | Antibody anti-APOA1BP |
| Status | RUO |
Descripción
Apolipoprotein A1 Binding Protein (APOA1BP), also known as NAXE, is an essential protein implicated in lipid metabolism and cellular detoxification processes. This protein is known for its interaction with apolipoprotein A1 (ApoA1), the primary protein component of high-density lipoprotein (HDL). APOA1BP is involved in HDL assembly and function, playing a crucial role in reverse cholesterol transport, wherein cholesterol is transported from peripheral tissues back to the liver for excretion. Additionally, APOA1BP exhibits enzymatic activity as NAD(P)HX epimerase, facilitating the repair of damaged nicotinamide adenine dinucleotide (NADH) or its phosphate form (NADPH), which are critical cofactors in cellular metabolism. This protective function is vital in maintaining cellular redox homeostasis and preventing metabolic dysfunction. Mutations or deficiencies in APOA1BP/NAXE have been linked to a rare neurological disorder characterized by progressive neurodegeneration and metabolic disturbances. As a result, it is increasingly recognized as a target for therapeutic exploration in metabolic and cardiovascular diseases. Understanding the structural and functional dynamics of APOA1BP continues to advance its potential applications in medical science.
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