Apolipoprotein A1 Binding Protein (APOA1BP) Antibody
312€ (100 µl)
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935106861
info@markelab.com
name
Apolipoprotein A1 Binding Protein (APOA1BP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104885
tested applications
WB, IHC, IF/ICC
Description
Apolipoprotein A1 Binding Protein Antibody is a Rabbit Polyclonal against Apolipoprotein A1 Binding Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein A1 Binding Protein (APOA1BP) |
| Host | Rabbit |
| Reactivity | Cow |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | NAXE AIBP,APOA1BP,YJEFN1 |
| Background | Antibody anti-APOA1BP |
| Status | RUO |
Descripción
Apolipoprotein A1 Binding Protein (APOA1BP), also known as NAXE, is an essential protein implicated in lipid metabolism and cellular detoxification processes. This protein is known for its interaction with apolipoprotein A1 (ApoA1), the primary protein component of high-density lipoprotein (HDL). APOA1BP is involved in HDL assembly and function, playing a crucial role in reverse cholesterol transport, wherein cholesterol is transported from peripheral tissues back to the liver for excretion. Additionally, APOA1BP exhibits enzymatic activity as NAD(P)HX epimerase, facilitating the repair of damaged nicotinamide adenine dinucleotide (NADH) or its phosphate form (NADPH), which are critical cofactors in cellular metabolism. This protective function is vital in maintaining cellular redox homeostasis and preventing metabolic dysfunction. Mutations or deficiencies in APOA1BP/NAXE have been linked to a rare neurological disorder characterized by progressive neurodegeneration and metabolic disturbances. As a result, it is increasingly recognized as a target for therapeutic exploration in metabolic and cardiovascular diseases. Understanding the structural and functional dynamics of APOA1BP continues to advance its potential applications in medical science.
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