NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial (SIRT5) Antibody
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Description
NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial (SIRT5) Antibody is a Rabbit polyclonal antibody for the detection of Human NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial (SIRT5).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial (SIRT5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NXA8 |
| Gene ID | 23408 |
| NCBI Accession | NP_001180196.1 |
| Background | Antibody anti-SIRT5 |
| Status | RUO |
Descripción
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Human SIRT5 (NAD-dependent deacetylase sirtuin-5) ELISA Kit
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SIRT5 antibody
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.
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