SIRT5 antibody
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935106861
info@markelab.com
name
SIRT5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07883
tested applications
ELISA, WB, IP
Description
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | sirtuin(silent mating type information regulation 2 homolog) 5 (SIRT5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 33 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NXA8 |
| Alias | NAD-dependent protein deacylase sirtuin-5, mitochondrial,Regulatory protein SIR2 homolog 5,SIR2-like protein 5,SIRT5,SIR2L5 |
| Background | Antibody anti-SIRT5 |
| Status | RUO |
| Note | Mol. Weight 33 kDa |
Descripción
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