N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody (Biotin)

Product specifications

Primary Antibodies

N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2)

Rabbit

Human

Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Biotin

IgG

> 95%

Purified by Protein G.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.

No

Q8N0V5

2651

NP_001482.1, NM_001491.2, NP_663624.1, NM_145649.4

600429

N-acetylglucosaminyltransferase,I-branching enzyme,CCAT,CTRCT13,GCNT2C,GCNT5,IGNT,NACGT1,NAGCT1,ULG3,bA360O19.2,bA421M1.1

Antibody anti-GCNT2

RUO

Descripción

Glucosaminyl (N-acetyl) transferase 2 (GCNT2), also known as the I-branching enzyme, catalyzes the addition of N-acetylglucosamine to linear oligosaccharides, forming the branched I antigen structure that characterizes the I blood group system GCNT2 is predominantly expressed in erythroid cells, epithelial tissues, and during embryonic development, where it is critical for glycan diversity and proper glycoprotein function Mutations in GCNT2 lead to the adult i phenotype, a rare blood group disorder characterized by persistent fetal-type linear glycans, hemolytic anemia, and immune vulnerabilities GCNT2’s activity also influences ocular health, with mutations linked to congenital cataracts and other lens abnormalities Emerging research highlights its role in embryogenesis and cell surface glycosylation, critical for cell signaling, adhesion, and differentiation Dysregulation of GCNT2 expression has further been associated with immune dysfunction and specific cancer pathways, emphasizing its role in glycoprotein branching and cellular homeostasis

Related Products

GCNT2 antibody

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Isoform C: Determines the expression of the blood group I antigen in erythrocytes.

Ver Producto

N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

Ver Producto

N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

Ver Producto