GCNT2 antibody

Product specifications

Primary Antibodies

glucosaminyl(N-acetyl) transferase 2, I-branching enzyme(I blood group) (GCNT2)

Rabbit

Human, Mouse, Rat

WB: 1:500-1:2000; IHC: 1:20-1:200

polyclonal

Unconjugated

IgG

46kd

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA, WB, IHC

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Q8N0V5

N-acetylglucosaminyltransferase,I-branching enzyme,CCAT,CTRCT13,GCNT2C,GCNT5,IGNT,NACGT1,NAGCT1,ULG3,bA360O19.2,bA421M1.1

Antibody anti-GCNT2

RUO

Mol. Weight 46 kDa

Descripción

Glucosaminyl (N-acetyl) transferase 2 (GCNT2), also known as the I-branching enzyme, catalyzes the addition of N-acetylglucosamine to linear oligosaccharides, forming the branched I antigen structure that characterizes the I blood group system GCNT2 is predominantly expressed in erythroid cells, epithelial tissues, and during embryonic development, where it is critical for glycan diversity and proper glycoprotein function Mutations in GCNT2 lead to the adult i phenotype, a rare blood group disorder characterized by persistent fetal-type linear glycans, hemolytic anemia, and immune vulnerabilities GCNT2’s activity also influences ocular health, with mutations linked to congenital cataracts and other lens abnormalities Emerging research highlights its role in embryogenesis and cell surface glycosylation, critical for cell signaling, adhesion, and differentiation Dysregulation of GCNT2 expression has further been associated with immune dysfunction and specific cancer pathways, emphasizing its role in glycoprotein branching and cellular homeostasis

Related Products

GCNT2 antibody

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Isoform C: Determines the expression of the blood group I antigen in erythrocytes.

Ver Producto

N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

Ver Producto

N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

Ver Producto