Myosin Regulatory Light Chain 2, Ventricular/Cardiac Muscle Isoform (MYL2) Antibody
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Description
Myosin Regulatory Light Chain 2, Ventricular/Cardiac Muscle Isoform (MYL2) Antibody is a Rabbit polyclonal antibody for the detection of Human Myosin Regulatory Light Chain 2, Ventricular/Cardiac Muscle Isoform (MYL2).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Myosin Regulatory Light Chain 2, Ventricular/Cardiac Muscle Isoform (MYL2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10916 |
| Gene ID | 4633 |
| NCBI Accession | NP_000423.2 |
| Background | Antibody anti-MYL2 |
| Status | RUO |
Descripción
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Contractile protein that plays a role in heart development and function(By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force(By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly(By similarity).
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MYL2, also named as MLC-2v and MLC-2, is ventricular/cardiac muscle isoform. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10). Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2). MYL2 has been widely used as a marker of mature ventricular cardiomyocytes.
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