MYL2 antibody
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Description
Contractile protein that plays a role in heart development and function(By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force(By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin, light chain 2, regulatory, cardiac, slow (MYL2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 18-20 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P10916 |
| Gene ID | 4633 |
| Alias | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2, MLC-2v),Cardiac myosin light chain 2,Myosin light chain 2, slow skeletal/ventricular muscle isoform (MLC-2s/v),Ventricular myosin light chain 2,MYL2,MLC2 |
| Background | Antibody anti-MYL2 |
| Status | RUO |
| Note | Mol. Weight 18-20 kDa |
Descripción
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MYL2 antibody
Contractile protein that plays a role in heart development and function(By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force(By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly(By similarity).
Ver ProductoMYL2 antibody
Ver ProductoMYL2 antibody
MYL2, also named as MLC-2v and MLC-2, is ventricular/cardiac muscle isoform. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10). Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2). MYL2 has been widely used as a marker of mature ventricular cardiomyocytes.
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