Myosin Light Chain Kinase 2 (MYLK2) Antibody
357.5€ (100 µg)
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935106861
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name
Myosin Light Chain Kinase 2 (MYLK2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037057
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the MYLK2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Myosin Light Chain Kinase 2 (MYLK2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | KMLC,MLCK,MLCK2,skMLCK,Myosin light chain kinase 2, skeletal cardiac muscle |
| Background | Antibody anti-MYLK2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Myosin light chain kinase 2 (MYLK2) is a muscle-specific isoform of myosin light chain kinase predominantly expressed in skeletal muscle tissue. MYLK2 plays a key role in regulating myosin activity during muscle contraction by phosphorylating the regulatory light chains of myosin II, a process critical for force generation and sarcomere function. The kinase activity of MYLK2 is tightly regulated by calcium-calmodulin signaling, ensuring precise control of contractile responses during dynamic skeletal muscle activities such as exercise and locomotion. MYLK2 also contributes to the adaptive remodeling of muscle fibers in response to mechanical stress and physiological demands. Mutations or dysregulation of MYLK2 have been associated with myopathies and muscle weakness, emphasizing its essential role in maintaining muscular integrity and function.
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