Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) Antibody

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383.5€ (100 µl)

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935106861
info@markelab.com
name
Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx011218
tested applications
ELISA, IHC

Description

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila). Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q03164
Gene ID
4297
OMIM
159555
Background
Antibody anti-MLL
Status
RUO
Note
Concentration: Not determined. -

Descripción

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