Muscle Skeletal Receptor Tyrosine Kinase Phospho-Tyr755 (MUSK pY755) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Muscle Skeletal Receptor Tyrosine Kinase Phospho-Tyr755 (MUSK pY755) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012739
tested applications
WB
Description
Rabbit polyclonal antibody against MuSK (Phospho-Tyr755) protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y755, M:Y754, R:Y754.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Muscle Skeletal Receptor Tyrosine Kinase Phospho-Tyr755 (MUSK pY755) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr755 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15146 |
| Alias | CMS9,FADS,FADS1,Muscle-specific tyrosine-protein kinase receptor,Muscle skeletal receptor tyrosine-protein kinase |
| Background | Antibody anti-MuSK |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Muscle-associated receptor tyrosine kinase (MUSK) is a critical protein in the formation and maintenance of the neuromuscular junction (NMJ), the synapse between motor neurons and muscle fibers. MUSK is essential for the proper functioning of the NMJ, playing a pivotal role in the signaling pathways that govern the assembly and stability of this specialized synapse. The NMJ is crucial for muscle contraction and overall motor function, and disruptions in MUSK function can lead to severe neuromuscular diseases. MUSK is encoded by the MUSK gene, located on chromosome 9 in humans. The protein belongs to the receptor tyrosine kinase family and is highly conserved across species, reflecting its essential role in muscle biology. MUSK activation is tightly regulated and involves interactions with several other proteins, including agrin, low-density lipoprotein receptor-related protein 4 (LRP4), and downstream effectors such as rapsyn.
Related Products
Muscle Skeletal Receptor Tyrosine Kinase Phospho-Tyr755 (MUSK pY755) Antibody
Rabbit polyclonal antibody against MuSK (Phospho-Tyr755) protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y755, M:Y754, R:Y754.
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