Muscarinic Acetylcholine Receptor M1 (CHRM1) Antibody (HRP)
169€ (20 µg)
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Name
Muscarinic Acetylcholine Receptor M1 (CHRM1) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx109011
Tested Applications
ELISA
Description
CHRM1 Antibody (HRP) is a Rabbit Polyclonal antibody against CHRM1 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Muscarinic Acetylcholine Receptor M1 (CHRM1) Immunogen: Recombinant Rat Muscarinic acetylcholine receptor M1 protein (210-366AA). |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08482 |
| Gene ID | 25229 |
| Alias | CHRM1,M1 muscarinic acetylcholine receptor,Chrm-1,M1R,cholinergic receptor muscarinic 1,cholinergic receptor,cholinergic receptor, muscarinic 1, M1 receptor,M1, HM1 |
| Background | Antibody anti-CHRM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CHRM1 encodes the cholinergic receptor muscarinic 1, which is a member of the muscarinic acetylcholine receptor family. These receptors are G protein-coupled receptors (GPCRs) that mediate the actions of acetylcholine, a key neurotransmitter in the central nervous system (CNS) and peripheral tissues. CHRM1 is primarily expressed in the cerebral cortex, hippocampus, and basal ganglia, playing an essential role in cognitive processes such as learning, memory, and attention. Activation of CHRM1 leads to the stimulation of phospholipase C (PLC) via Gq/11 proteins, which increases intracellular calcium ion concentration and activates protein kinase C (PKC). Dysregulation of CHRM1 has been associated with neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and epilepsy. Pharmacologically, CHRM1 agonists enhance cognitive function, while antagonists can alleviate conditions like muscle spasms and excessive salivation. CHRM1 remains a critical target in neurodegenerative research, as modulation of this receptor may restore acetylcholine signaling and improve cognitive decline.
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