Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody (Biotin)
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx315561
Tested Applications
ELISA
Description
ABCC4 Antibody (Biotin) is a Rabbit Polyclonal against ABCC4 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Multidrug Resistance-Associated Protein 4 (ABCC4) Immunogen: Recombinant Human Multidrug resistance-associated protein 4 protein (562-697AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15439 |
| Gene ID | 10257 |
| NCBI Accession | NP_001098985.1, NM_001105515.2, NP_001288758.1, NM_001301829.1, NP_001288759.1, NM_001301830.1, NP_005836.2, NM_005845.4 |
| OMIM | 605250 |
| Alias | MOAT-B,MOATB,MRP4,Multidrug resistance-associated protein 4 |
| Background | Antibody anti-ABCC4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABCC4, also known as multidrug resistance-associated protein 4 (MRP4), is an ATP-binding cassette transporter expressed in various tissues, including the liver, kidneys, and endothelial cells of the blood-brain barrier. It exports a wide range of substrates, including cyclic nucleotides, prostaglandins, antiviral drugs, and chemotherapeutic agents, from cells. ABCC4’s activity plays a critical role in cellular signaling by regulating intracellular levels of cyclic AMP and GMP. It is also involved in drug resistance, where its overexpression limits the intracellular accumulation of therapeutic agents. ABCC4 is upregulated in response to oxidative stress and inflammation, highlighting its role in protecting cells from toxic insults. Its diverse substrate specificity and involvement in drug efflux make ABCC4 a significant target in pharmacological research and disease management.
Productos relacionados
Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
ABCC4 Antibody is a Rabbit Polyclonal antibody against ABCC4. The protein encoded by this gene is a member of the superf…
Ver producto
Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins …
Ver producto
Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins …
Ver producto