Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
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935106861
info@markelab.com
Precio
162.5€ (20 µg)
Antibody anti-ABCC4
proveedor
Abbexareference
abx301046Tested Applications
ELISA, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
ABCC4 Antibody is a Rabbit Polyclonal against ABCC4.
Background
ABCC4, also known as multidrug resistance-associated protein 4 (MRP4), is an ATP-binding cassette transporter expressed in various tissues, including the liver, kidneys, and endothelial cells of the blood-brain barrier. It exports a wide range of substrates, including cyclic nucleotides, prostaglandins, antiviral drugs, and chemotherapeutic agents, from cells. ABCC4’s activity plays a critical role in cellular signaling by regulating intracellular levels of cyclic AMP and GMP. It is also involved in drug resistance, where its overexpression limits the intracellular accumulation of therapeutic agents. ABCC4 is upregulated in response to oxidative stress and inflammation, highlighting its role in protecting cells from toxic insults. Its diverse substrate specificity and involvement in drug efflux make ABCC4 a significant target in pharmacological research and disease management.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Multidrug Resistance-Associated Protein 4 (ABCC4)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IF/ICC
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ABCC4
dry ice
No
availability
Shipped within 5-10 working days.
alias
MOAT-B,MOATB,MRP4,Multidrug resistance-associated protein 4
uniprot id
NCBI accession
NP_001098985.1, NM_001105515.2, NP_001288758.1, NM_001301829.1, NP_001288759.1, NM_001301830.1, NP_005836.2, NM_005845.4
note
This product is for research use only.
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