Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
468€ (100 µl)
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Name
Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx117250
Tested Applications
ELISA, WB, IHC
Description
ABCC4 Antibody is a Rabbit Polyclonal antibody against ABCC4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Multidrug Resistance-Associated Protein 4 (ABCC4) Immunogen: Recombinant protein of human ABCC4. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15439 |
| Gene ID | 10257 |
| Alias | MOAT-B,MOATB,MRP4,Multidrug resistance-associated protein 4 |
| Background | Antibody anti-ABCC4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABCC4, also known as multidrug resistance-associated protein 4 (MRP4), is an ATP-binding cassette transporter expressed in various tissues, including the liver, kidneys, and endothelial cells of the blood-brain barrier. It exports a wide range of substrates, including cyclic nucleotides, prostaglandins, antiviral drugs, and chemotherapeutic agents, from cells. ABCC4’s activity plays a critical role in cellular signaling by regulating intracellular levels of cyclic AMP and GMP. It is also involved in drug resistance, where its overexpression limits the intracellular accumulation of therapeutic agents. ABCC4 is upregulated in response to oxidative stress and inflammation, highlighting its role in protecting cells from toxic insults. Its diverse substrate specificity and involvement in drug efflux make ABCC4 a significant target in pharmacological research and disease management.
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