Multidrug Resistance Associated Protein 1 (ABCC1) Antibody
260€ (50 µl)
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Name
Multidrug Resistance Associated Protein 1 (ABCC1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx210610
Tested Applications
ELISA, IHC
Description
Multidrug Resistance Associated Protein 1 (ABCC1) Antibody is a Rabbit Polyclonal against Multidrug Resistance Associated Protein 1 (ABCC1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Multidrug Resistance Associated Protein 1 (ABCC1) Immunogen: Synthetic peptide of human ABCC1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P33527 |
| Gene ID | 4363 |
| Alias | ABC29,ABCC,DFNA77,GS-X,MRP,MRP1 |
| Background | Antibody anti-ABCC1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ABCC1, also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane ATP-binding cassette transporter that effluxes a wide range of substrates, including drugs, xenobiotics, and endogenous molecules such as glutathione, leukotrienes, and conjugated metabolites. It is highly expressed in barrier tissues, such as the blood-brain barrier, lungs, and liver, where it protects cells by exporting potentially toxic compounds. ABCC1 plays a key role in multidrug resistance, as its overexpression in cancer cells reduces the efficacy of chemotherapeutic agents by actively transporting them out of cells. Structurally, ABCC1 contains two transmembrane domains and two ATP-binding domains that enable ATP-driven substrate transport. Dysregulation of ABCC1 activity is implicated in various pathological conditions, including drug resistance, inflammation, and oxidative stress, making it a target for therapeutic intervention in oncology and pharmacology.
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