Multidrug Resistance Associated Protein 1 (ABCC1) Antibody
273€ (100 µl)
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935106861
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name
Multidrug Resistance Associated Protein 1 (ABCC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104170
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Multidrug Resistance Associated Protein 1 (MRP1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Multidrug Resistance Associated Protein 1 (ABCC1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC29,ABCC,DFNA77,GS-X,MRP,MRP1 |
| Background | Antibody anti-ABCC1 |
| Status | RUO |
Descripción
ABCC1, also known as multidrug resistance-associated protein 1 (MRP1), is a transmembrane ATP-binding cassette transporter that effluxes a wide range of substrates, including drugs, xenobiotics, and endogenous molecules such as glutathione, leukotrienes, and conjugated metabolites. It is highly expressed in barrier tissues, such as the blood-brain barrier, lungs, and liver, where it protects cells by exporting potentially toxic compounds. ABCC1 plays a key role in multidrug resistance, as its overexpression in cancer cells reduces the efficacy of chemotherapeutic agents by actively transporting them out of cells. Structurally, ABCC1 contains two transmembrane domains and two ATP-binding domains that enable ATP-driven substrate transport. Dysregulation of ABCC1 activity is implicated in various pathological conditions, including drug resistance, inflammation, and oxidative stress, making it a target for therapeutic intervention in oncology and pharmacology.
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies(ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
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