Mucin-1 (MUC1) Antibody
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Description
Mucin-1 (MUC1) Antibody is a monoclonal Mouse antibody for the detection of MUC1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mucin-1 (MUC1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | P280 |
| Purity | > 95% |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1-2 weeks. For long-term storage, aliquot and store at -20 °C or -80 °C. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15941 |
| Alias | Cancer antigen 15-3,CA 15-3,EMA,MCD,PEM,PUM,KL-6,MAM6,MCKD,PEMT,CD227,H23AG,MCKD1,MUC-1,ADMCKD, ADTKD2,Ca15-3,MUC-1,Episialin |
| Background | Antibody anti-MUC1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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MUC1 antibody
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
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