Mucin 1 Phospho-Tyr1229 (MUC1 pY1229) Antibody

Este producto es parte de MUC1 - mucin 1
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52€ (10 µg)

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935106861
info@markelab.com
name
Mucin 1 Phospho-Tyr1229 (MUC1 pY1229) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012517
tested applications
ELISA, WB, IHC, IF/ICC

Description

Rabbit polyclonal antibody against CD227/MUC1 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y1229.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Mucin 1 Phospho-Tyr1229 (MUC1 pY1229)
Host
Rabbit
Reactivity
Human
Assay Data
Modification: Phosphorylation // Target Modification: Tyr1229
Recommended Dilution
WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/500, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P15941
Gene ID
4582
NCBI Accession
NP_001018016.1, NM_001018016.2
OMIM
113720
Alias
Cancer antigen 15-3,CA 15-3,EMA,MCD,PEM,PUM,KL-6,MAM6,MCKD,PEMT,CD227,H23AG,MCKD1,MUC-1,ADMCKD, ADTKD2,Ca15-3,MUC-1,Episialin
Background
Antibody anti-MUC1
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

MUC1 (Mucin 1) is a large, transmembrane glycoprotein predominantly expressed on the surface of epithelial cells in various tissues, including the lungs, stomach, intestines, and the mammary glands. As a mucin protein, MUC1 plays a critical role in forming a protective mucous barrier on epithelial surfaces, which protects against environmental and microbial challenges. MUC1 also contributes to cell signaling and modulation of the immune response, particularly in epithelial cell inflammation. Due to its protective function on epithelial tissues, MUC1 expression is typically restricted to the apical surface of cells. However, in pathological states like cancer, MUC1 expression becomes dysregulated. Overexpression, aberrant glycosylation, and loss of polarity are commonly observed in many epithelial cancers, including breast, ovarian, and pancreatic cancers. These modifications contribute to tumor development, cancer cell survival, and metastasis, making MUC1 a key target for cancer diagnostics and therapeutics. In addition to cancer, MUC1 is associated with certain inflammatory and infectious diseases due to its role in the immune system.

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