Mucin-1 (MUC1) Antibody

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Description
Mucin-1 (MUC1) Antibody is a Human Monoclonal antibody for the detection of Mucin-1 (MUC1) in Human samples.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Mucin-1 (MUC1) |
Host | Human |
Reactivity | Human |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Clone ID | C387 |
Purity | > 95% |
Purification | Purified by Protein A/G affinity chromatography. |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC, FCM |
Buffer | 0.01 M PBS, pH 7.4. |
Availability | Shipped within 5-12 working days. |
Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
Dry Ice | No |
UniProt ID | P15941 |
Gene ID | 4582 |
Alias | Cancer antigen 15-3,CA 15-3,EMA,MCD,PEM,PUM,KL-6,MAM6,MCKD,PEMT,CD227,H23AG,MCKD1,MUC-1,ADMCKD, ADTKD2,Ca15-3,MUC-1,Episialin |
Background | Antibody anti-MUC1 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
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MUC1 antibody
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
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