Mu-type opioid receptor Phospho-Ser375 (OPRM1 pS375) Antibody
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Description
OPRM1 (pS375) Antibody is a Rabbit Polyclonal against OPRM1 (pS375).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mu-type opioid receptor Phospho-Ser375 (OPRM1 pS375) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Ser375 |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35372 |
| Gene ID | 4988 |
| Alias | OPRM1,Mu receptor,MOP,OP3,MOPr,opioid receptor,mu 1,opioid receptor,MOR,LMOR,MOR1,OPRM,M-OR-1 |
| Background | Antibody anti-OPRM1 |
| Status | RUO |
Descripción
OPRM1, or the mu-opioid receptor, is the primary target for endogenous opioid peptides like endorphins and exogenous opioids such as morphine, fentanyl, and heroin. OPRM1 is highly expressed in pain-processing regions of the CNS, including the brainstem, thalamus, and spinal cord, where it mediates analgesia, euphoria, and sedation. OPRM1 couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to decrease neuronal excitability and neurotransmitter release. Activation of OPRM1 produces potent analgesic effects but also carries risks of tolerance, dependence, and respiratory depression. Dysregulation of OPRM1 signaling is central to opioid addiction, chronic pain, and reward pathways. Selective modulation of OPRM1 has therapeutic potential for improving pain management while reducing side effects such as tolerance and dependence. Biased agonists that preferentially activate analgesic pathways over adverse effects are under development to enhance safety. OPRM1 remains a key target for opioids and therapies addressing addiction and pain disorders.
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OPRM1 Antibody is a Rabbit Polyclonal antibody against OPRM1. This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
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