Mouse Vascular Cell Adhesion Protein 1 (VCAM1) Protein

Product specifications

Proteins and Peptides

HEK293 cells

Mouse

Molecular Weight: Calculated MW: 72 kDa  Observed MW (SDS-PAGE): 117 kDa
Sequence Fragment: Met1-Glu698
Tag: C-terminal His tag

Recombinant

>90% (SDS-PAGE)

20 µg

100 µg

Lyophilized Reconstitute in sterile H2O. Do not vortex.

SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.

Shipped within 5-15 working days.

Store lyophilized between -20 °C and -80 °C.

No

P29533

22329

V-CAM 1,VCAM-1,INCAM-100,CD106

Protein VCAM1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

VCAM1 is a transmembrane glycoprotein and member of the immunoglobulin superfamily that plays a key role in cell adhesion, particularly in leukocyte-endothelial interactions during inflammation VCAM1 is expressed on endothelial cells in response to pro-inflammatory cytokines such as TNF-α and IL-1β where it mediates the adhesion and transmigration of leukocytes, including monocytes and lymphocytes, into inflamed tissues VCAM1 interacts with its ligand VLA-4 (integrin α4β1) to facilitate immune cell recruitment during acute and chronic inflammatory responses VCAM1 is implicated in various diseases including atherosclerosis, where it promotes monocyte adhesion to endothelial cells and contributes to plaque formation Elevated VCAM1 levels are also associated with rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders, where persistent inflammation leads to tissue damage VCAM1 serves as a biomarker for endothelial activation and vascular inflammation, making it a potential target for therapeutic interventions aimed at reducing leukocyte recruitment and chronic inflammation

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This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.

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