Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits UCHL5
proveedor
Abbexareference
abx552449Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Ubiquitin carboxyl-terminal hydrolase isozyme L5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
UCHL5, also known as UCH37, is a deubiquitinating enzyme (DUB) that plays a key role in the ubiquitin-proteasome system by removing ubiquitin chains from proteasomal substrates, thereby regulating protein turnover and degradation. UCHL5 interacts with the 19S regulatory particle of the 26S proteasome, facilitating the recycling of ubiquitin to maintain cellular proteostasis. It is involved in DNA repair, cell cycle progression, and stress responses, making it crucial for cellular homeostasis. UCHL5 has also been implicated in tumorigenesis, where its overexpression promotes cell survival, proliferation, and chemoresistance by preventing the degradation of oncogenic proteins. Inhibitors of UCHL5 have shown potential as anti-cancer agents by enhancing proteasomal degradation of key regulatory proteins. Knockdown studies reveal its role in impaired cell growth, defective DNA repair, and increased apoptosis, highlighting UCHL5's importance in protein homeostasis, cellular stability, and cancer progression.
Características del producto
category
ELISA Kits
immunogen target
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
UCH37,CGI-70,INO80R,UCH-L5,Ubiquitin carboxyl-terminal hydrolase isozyme L5,Ubiquitin thioesterase L5
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
UCHL5
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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