Mouse TNFSF13 (Tumor necrosis factor ligand superfamily member 13) ELISA Kit

Este producto es parte de TNFSF13 - TNF superfamily member 13
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935106861
info@markelab.com
name
Mouse TNFSF13 (Tumor necrosis factor ligand superfamily member 13) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EM0672
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
0.625-40ng/ml
Sensitivity
0.375ng/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
Q9D777
Alias
Tumor necrosis factor ligand superfamily member 13,APRIL,CD256,TALL2,ZTNF2,TALL-2,TNLG7B,TRDL-1,A proliferation-inducing ligand,TNF- and APOL-related leukocyte expressed ligand 2,TNF-related death ligand 1
Background
Elisa kits for TNFSF13
Status
RUO

TNFSF13, also known as APRIL (A Proliferation-Inducing Ligand), is a protein within the tumor necrosis factor (TNF) superfamily involved in immune system regulation, especially in B-cell survival, proliferation, and antibody production. This ligand, encoded by the TNFSF13 gene, binds to specific receptors on immune cells, including TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor) and BCMA (B-Cell Maturation Antigen), to initiate signaling pathways that promote immune responses and sustain humoral immunity. APRIL, along with BAFF (B-cell Activating Factor), another TNF family ligand, is essential for adaptive immunity, supporting B cell maturation and differentiation. APRIL is mainly expressed by myeloid cells, such as dendritic cells and macrophages, and some types of lymphoid cells. Beyond its role in immune cell survival, APRIL has clinical significance, as its overexpression has been associated with autoimmune diseases, certain cancers, and inflammatory disorders. The APRIL/BAFF signaling pathways represent crucial targets for immunotherapy, especially in treating autoimmune diseases and B-cell malignancies.

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