Mouse TNF Receptor Associated Factor 1 (TRAF1) Protein

Este producto es parte de TRAF - TNF receptor associated factor
Mouse TNF Receptor Associated Factor 1 (TRAF1) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein TRAF1

proveedor

Abbexa

reference

abx069346

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant TRAF1 (TRAF1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

TRAF1 is an adaptor protein in the tumor necrosis factor receptor (TNFR) superfamily signaling pathways, playing a role in regulating NF-κB and MAPK activation, apoptosis, and immune responses. TRAF1 interacts with TNFR1, TNFR2, and other members of the TNF receptor family to mediate downstream signaling, promoting survival and inflammatory responses. TRAF1 is predominantly expressed in immune cells, including T cells, B cells, and macrophages, where it modulates cytokine production and apoptosis inhibition. It forms heterodimers with TRAF2 to regulate receptor complex formation and downstream signal transduction. Dysregulation of TRAF1 contributes to autoimmune diseases, chronic inflammation, and certain cancers by altering TNF signaling and immune responses. Knockdown studies show defects in cytokine production, reduced NF-κB activation, and increased susceptibility to apoptosis, underscoring its role in balancing immune homeostasis and cell survival pathways.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

TNF Receptor Associated Factor 1 (TRAF1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 29.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu169-Ala392 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TRAF1


dry ice

No


availability

Shipped within 5-7 working days.


alias

TRAF-1,TRAF1,EBI6, MGC:10353, TNF receptor associated factor 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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