Mouse T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) ELISA Kit

Este producto es parte de CD8 subunit
Mouse T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for CD8B

proveedor

Abbexa

reference

abx556100

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.

Características del producto

category

ELISA Kits


immunogen target

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.075 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

CD8B


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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