935106861
info@markelab.com
Precio
687.5€ (96 tests)
Mouse Switch-associated protein 70 (SWAP70) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Switch-associated protein 70 concentrations in tissue homogenates, cell lysates and other biological fluids.
SWAP70 is a nuclear and cytoplasmic adaptor protein involved in actin cytoskeleton remodeling, signal transduction, and B-cell activation. It functions as a guanine nucleotide exchange factor (GEF) for Rac1, facilitating actin polymerization and cell shape changes during processes such as immune cell migration, phagocytosis, and endocytosis. SWAP70 plays a critical role in B-cell development, class switch recombination (CSR), and antigen receptor signaling, linking extracellular signals to cytoskeletal rearrangement and nuclear responses. It is expressed in hematopoietic cells, epithelial tissues, and immune cells, where it coordinates cell migration, adhesion, and immune responses. Dysregulation of SWAP70 is associated with autoimmune diseases, cancer metastasis, and inflammatory disorders due to impaired actin regulation and signaling balance. Knockout studies reveal defects in B-cell maturation, impaired immune cell migration, and reduced immune responses, highlighting its essential role in cytoskeletal remodeling, cell signaling, and adaptive immunity.
ELISA Kits
Switch-associated protein 70 (SWAP70)
Mouse
0.156 ng/ml - 10 ng/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
SWAP70
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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