Mouse Suppressor of Cytokine Signaling 5 (SOCS5) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SOCS5
proveedor
Abbexareference
abx546664Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Suppressor of Cytokine Signaling 5 (SOCS5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Suppressor of Cytokine Signaling 5 (SOCS5) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
SOCS5 acts as a negative regulator of cytokine signaling by inhibiting JAK/STAT pathways and targeting signaling components for proteasomal degradation through its SOCS box domain. It interacts with cytokine receptors like IL-4Rα to regulate T-helper cell differentiation, particularly inhibiting Th2 responses and promoting immune balance. SOCS5 is expressed in lymphoid tissues, epithelial cells, and adipose tissues, where it modulates immune regulation, cytokine sensitivity, and energy homeostasis. It is particularly important for regulating allergic inflammation and T-cell polarization during immune responses. Dysregulation of SOCS5 is associated with allergic diseases, asthma, and autoimmune disorders due to imbalanced cytokine signaling. Functional studies reveal its role in controlling IL-4-driven responses, preventing excessive Th2-mediated inflammation. Knockout models demonstrate enhanced Th2 differentiation, increased allergic inflammation, and disrupted immune balance, emphasizing its role in maintaining cytokine homeostasis and adaptive immunity.
Características del producto
category
ELISA Kits
immunogen target
Suppressor of Cytokine Signaling 5 (SOCS5)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
SOCS5,CIS6, CISH6, Cish5, SOCS-5,Cytokine-inducible SH2 protein 6,CIS-6,Cytokine-inducible SH2-containing protein 5,Cytokine-inducible SH2-containing protein 5
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SOCS5
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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