Mouse Suppression of tumorigenicity 5 protein (DENND2B) ELISA Kit

Name: Mouse Suppression of tumorigenicity 5 protein (DENND2B) ELISA Kit
Brand: Abbexa
SKU: abx547569
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de DENND - DENN domain containing

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DENND2B

proveedor

Abbexa

reference

abx547569

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Suppression of tumorigenicity 5 protein (DENND2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Suppression of tumorigenicity 5 protein concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

DENN domain containing 2B (DENND2B) is a guanine nucleotide exchange factor (GEF) that specifically activates Rab GTPases, particularly Rab9, facilitating vesicular trafficking between late endosomes and the trans-Golgi network. Through its DENN domain, DENND2B promotes the GDP-GTP exchange on Rab9, thereby enabling the transport of vesicles containing enzymes, receptors, and other cargo necessary for lysosomal and Golgi function. DENND2B plays a crucial role in maintaining the integrity of lysosomal and endosomal compartments and is involved in processes such as protein recycling and cellular nutrient homeostasis. Its expression is widespread, with enhanced activity in tissues requiring high levels of vesicle transport, such as neural and immune cells. Dysregulation of DENND2B has been implicated in neurodegenerative and metabolic disorders, where defects in vesicle trafficking lead to the accumulation of undegraded substrates and disrupted cellular signaling.

Características del producto

immunogen target

Suppression of tumorigenicity 5 protein (DENND2B)

reactivity

Mouse

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

ST5,HTS1,p126,ST5,Suppression of tumorigenicity 5 protein,HeLa tumor suppression 1

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

DENND2B

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q924W7

gene id

https://www.ncbi.nlm.nih.gov/gene/76954

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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