Mouse Suppression of tumorigenicity 5 protein (DENND2B) ELISA Kit
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Description
Mouse Suppression of tumorigenicity 5 protein (DENND2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Suppression of tumorigenicity 5 protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Suppression of tumorigenicity 5 protein (DENND2B) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q924W7 |
| Gene ID | 76954 |
| Alias | ST5,HTS1,p126,ST5,Suppression of tumorigenicity 5 protein,HeLa tumor suppression 1 |
| Background | Elisa kits for DENND2B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 2B (DENND2B) is a guanine nucleotide exchange factor (GEF) that specifically activates Rab GTPases, particularly Rab9, facilitating vesicular trafficking between late endosomes and the trans-Golgi network. Through its DENN domain, DENND2B promotes the GDP-GTP exchange on Rab9, thereby enabling the transport of vesicles containing enzymes, receptors, and other cargo necessary for lysosomal and Golgi function. DENND2B plays a crucial role in maintaining the integrity of lysosomal and endosomal compartments and is involved in processes such as protein recycling and cellular nutrient homeostasis. Its expression is widespread, with enhanced activity in tissues requiring high levels of vesicle transport, such as neural and immune cells. Dysregulation of DENND2B has been implicated in neurodegenerative and metabolic disorders, where defects in vesicle trafficking lead to the accumulation of undegraded substrates and disrupted cellular signaling.
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Guanine nucleotide exchange factor(GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
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Guanine nucleotide exchange factor(GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.
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