Mouse Sirtuin 1 (SIRT1) Protein

Este producto es parte de SIRT1 - Sirtuin 1
Product Graph
208€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Sirtuin 1 (SIRT1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069100
tested applications
WB, SDS-PAGE

Description

Recombinant Sirtuin 1 (SIRT1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Sirtuin 1 (SIRT1)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 30.0 kDa  Observed MW (SDS-PAGE): 30 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Glu236-Ala490
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q923E4
Alias
SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1
Background
Protein SIRT1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders

Related Products

abx196269

Human Sirtuin 1 (SIRT1) CLIA Kit

Human Sirtuin 1 (SIRT1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Sirtuin 1 (SIRT1).

Ver Producto
abx272846

Sirtuin 1 (SIRT1) Antibody (Biotin)

Sirtuin 1 (SIRT1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Sirtuin 1 (SIRT1).

Ver Producto
abx325391

Sirtuin 1 Phospho-Ser47 (SIRT1 pS47) Antibody

SIRT1 (pS47) Antibody is a Rabbit Polyclonal against SIRT1 (pS47).

Ver Producto