Mouse SH3 domain-containing kinase-binding protein 1 (SH3KBP1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse SH3 domain-containing kinase-binding protein 1 (SH3KBP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545676
tested applications
ELISA
Description
Mouse SH3 domain-containing kinase-binding protein 1 (SH3KBP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH3 domain-containing kinase-binding protein 1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH3 domain-containing kinase-binding protein 1 (SH3KBP1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8R550 |
| Gene ID | 58194 |
| Alias | SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2,Ruk |
| Background | Elisa kits for SH3KBP1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH3 Domain Containing Kinase Binding Protein 1 (SH3KBP1), also known as CIN85 (Cbl-interacting protein of 85 kDa), is a multi-domain adaptor protein involved in numerous cellular signaling pathways. It contains SH3 domains that facilitate interactions with various binding partners, making it a critical regulator of receptor endocytosis, cytoskeletal reorganization, and intracellular trafficking. SH3KBP1 plays a key role in downregulating activated receptor tyrosine kinases, such as EGFR, by recruiting ubiquitin ligases like Cbl, leading to receptor internalization and degradation. Additionally, it is implicated in actin cytoskeleton dynamics, thereby influencing processes such as cell migration and adhesion. SH3KBP1 also participates in immune signaling and synaptic transmission by modulating vesicular transport. Dysregulation of SH3KBP1 has been associated with cancer, particularly in pathways involving aberrant receptor signaling, as well as other diseases linked to defective endocytic or cytoskeletal mechanisms.
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