Mouse SH2 domain-containing protein 2A (SH2D2A) ELISA Kit
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Description
Mouse SH2 domain-containing protein 2A (SH2D2A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH2 domain-containing protein 2A concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2 domain-containing protein 2A (SH2D2A) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9QXK9 |
| Gene ID | 27371 |
| Alias | SH2D2A,F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A |
| Background | Elisa kits for SH2D2A |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2D2A, also known as SCOP (SH2 domain-containing phosphatase), is an SH2 domain-containing adaptor protein that regulates T-cell receptor (TCR) and cytokine receptor signaling pathways. It is primarily expressed in T cells and other hematopoietic cells, where it modulates immune cell activation, proliferation, and cytokine production. SH2D2A functions by binding to phosphorylated receptors and signaling intermediates, linking TCR activation to downstream pathways like NF-κB, MAPK, and PI3K/Akt. It plays an important role in T-cell activation, survival, and differentiation, particularly during immune responses. Dysregulation of SH2D2A is associated with immune dysfunction, autoimmune diseases, and impaired T-cell responses. Knockout studies demonstrate defects in T-cell activation, reduced cytokine production, and impaired antigen-specific responses, underscoring its role as a critical regulator of TCR signaling and adaptive immunity.
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