Mouse SH2 domain-containing protein 2A (SH2D2A) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SH2D2A
proveedor
Abbexareference
abx545634Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse SH2 domain-containing protein 2A (SH2D2A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse SH2 domain-containing protein 2A concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH2D2A, also known as SCOP (SH2 domain-containing phosphatase), is an SH2 domain-containing adaptor protein that regulates T-cell receptor (TCR) and cytokine receptor signaling pathways. It is primarily expressed in T cells and other hematopoietic cells, where it modulates immune cell activation, proliferation, and cytokine production. SH2D2A functions by binding to phosphorylated receptors and signaling intermediates, linking TCR activation to downstream pathways like NF-κB, MAPK, and PI3K/Akt. It plays an important role in T-cell activation, survival, and differentiation, particularly during immune responses. Dysregulation of SH2D2A is associated with immune dysfunction, autoimmune diseases, and impaired T-cell responses. Knockout studies demonstrate defects in T-cell activation, reduced cytokine production, and impaired antigen-specific responses, underscoring its role as a critical regulator of TCR signaling and adaptive immunity.
Características del producto
category
ELISA Kits
immunogen target
SH2 domain-containing protein 2A (SH2D2A)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
SH2D2A,F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SH2D2A
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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