Mouse PTPRN (Protein Tyrosine Phosphatase Receptor Type N) ELISA Kit
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name
Mouse PTPRN (Protein Tyrosine Phosphatase Receptor Type N) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EM1322
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.781-50ng/ml |
| Sensitivity | 0.469ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q60673 |
| Alias | IA2,IA-2,ICA512,R-PTP-N,IA-2/PTP,Islet cell autoantigen 3,PTP IA-2,Islet cell antigen 512,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N |
| Background | Elisa kits for PTPRN |
| Status | RUO |
PTPRN, also known as IA-2, is a receptor-like protein tyrosine phosphatase predominantly expressed in neuroendocrine tissues, particularly in pancreatic β-cells. Structurally, it features a single transmembrane domain and an intracellular region that lacks phosphatase activity due to critical residue substitutions. PTPRN functions as a key regulator of insulin secretion and is essential for the formation and stability of secretory granules in endocrine cells. It interacts with granule components to facilitate the docking and exocytosis of insulin and other hormones. PTPRN is also an autoantigen in type 1 diabetes mellitus (T1DM), where autoimmune responses against it lead to β-cell destruction. Its role in neuroendocrine cell function emphasizes its importance in glucose homeostasis and diabetes pathogenesis. Mutations or dysregulation of PTPRN have been implicated in metabolic disorders and neurodegenerative diseases.
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