Mouse Proteinase-Activated Receptor 4 (F2RL3) ELISA Kit

Este producto es parte de F2R - Proteinase-Activated Receptor
Mouse Proteinase-Activated Receptor 4 (F2RL3) ELISA Kit

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935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for F2RL3

proveedor

Abbexa

reference

abx520599

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Proteinase-Activated Receptor 4 (F2RL3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Proteinase-activated receptor 4 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Proteinase-Activated Receptor 4 (F2RL3), or PAR4, is activated by thrombin and other serine proteases, including trypsin. It is primarily expressed in platelets, endothelial cells, and various immune cells. F2RL3 plays a crucial role in platelet aggregation, clot formation, and wound healing. Upon activation, PAR4 signals through Gi proteins to modulate cellular responses such as platelet activation, granule release, and thrombus formation. PAR4 is a key mediator of thrombin-induced platelet responses and works in concert with other PARs (like PAR1 and PAR3) to regulate the coagulation cascade. Dysregulation of F2RL3 signaling has been associated with thrombotic disorders, such as deep vein thrombosis and stroke. PAR4 antagonists are being investigated for their potential to prevent thrombosis, especially in cardiovascular diseases where clot formation is a major contributor to disease progression. Additionally, F2RL3’s role in immune cell activation and inflammation suggests it could be a target for managing inflammatory diseases and autoimmune disorders, as well as regulating immune responses during infection.

Características del producto

category

ELISA Kits


immunogen target

Proteinase-Activated Receptor 4 (F2RL3)


reactivity

Mouse


test range

0.312 ng/ml - 20 ng/ml


assay type

Competitive


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

F2RL3,coagulation factor II receptor-like 3,protease-activated receptor 4,thrombin receptor-like 3,thrombin receptor-like 3,F2R like thrombin/trypsin receptor 3,PAR4


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

F2RL3


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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