Mouse Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse F2RL2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Proteinase-Activated Receptor 3 (F2RL2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O08675 |
| Gene ID | 14064 |
| Alias | F2RL2,coagulation factor II receptor-like 2,protease-activated receptor 3,thrombin receptor-like 2,PAR-3,PAR3 |
| Background | Elisa kits for F2RL2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Proteinase-Activated Receptor 3 (F2RL2), also known as PAR3, is another member of the PAR family of receptors. It is primarily expressed in platelets, endothelial cells, and the gastrointestinal tract. F2RL2 is activated by thrombin, which cleaves the receptor to reveal a tethered ligand that activates intracellular signaling. Unlike other PARs, F2RL2 acts in concert with F2RL1 (PAR2) to modulate thrombin-induced platelet activation and coagulation. F2RL2 couples to Gi and Gq proteins, triggering a variety of signaling events such as platelet aggregation, smooth muscle contraction, and endothelial cell activation. Its primary role is in regulating hemostasis and thrombus formation, particularly during tissue injury or inflammation. Dysregulation of F2RL2 signaling can contribute to thrombosis, atherosclerosis, and ischemic conditions. Targeting F2RL2 offers therapeutic potential in cardiovascular diseases, particularly those involving abnormal platelet activation and clot formation, by preventing excessive thrombosis without impairing normal wound healing.
Related Products
Proteinase Activated Receptor 3 (F2RL2) Antibody
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
Ver Producto
Proteinase Activated Receptor 3 (F2RL2) Antibody
F2RL2 Antibody is a Rabbit Polyclonal antibody against F2RL2.
Ver Producto
Human Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit
Human Proteinase-Activated Receptor 3 (F2RL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protease Activated Receptor 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto